James Dewey Watson, the American molecular biologist who co-discovered the double helix structure of DNA with Francis Crick in 1953, died on November 6, 2025, at age 97 in East Northport, New York. Watson, Crick, and Maurice Wilkins shared the 1962 Nobel Prize in Physiology or Medicine.

Their landmark paper in Nature was built partly on X-ray crystallography work by Rosalind Franklin. Watson later served as director of Cold Spring Harbor Laboratory (1968-2007). His discovery revolutionized genetics, molecular biology, and biotechnology, enabling advances from genome sequencing to CRISPR gene editing.